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Objective@#To investigate the expression of Golgi protein 73 (GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis.@*Methods@#A total of 160 patients with liver cirrhosis (96 males, 64 females, age: (58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age: (53.5±12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin (ALB), total bilirubin (TBIL) and prothrombin time (PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among patients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis.@*Results@#The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5 μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4%, and the specificity was 87.8%. After combining with AFP, the sensitivity and specificity were elevated to 71.6% and 90.2% respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different (F: 3.15, 2.82, both P<0.05), and GP73 levels among groups also showed significant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r values: 0.362, -0.428, 0.672, 0.575, all P<0.01).@*Conclusion@#Serum GP73 level increases with progression of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis.
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Objective To investigate the expression of Golgi protein 73 ( GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis. Methods A total of 160 patients with liver cirrhosis (96 males, 64 females, age:(58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age: (53.5± 12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin ( ALB) , total bilirubin ( TBIL) and prothrombin time ( PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among pa-tients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic ( ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis. Results The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4％, and the specificity was 87.8％. After combining with AFP, the sensitivity and specificity were elevated to 71.6％ and 90.2％ respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different ( F:3.15, 2.82, both P<0.05) , and GP73 levels among groups also showed sig-nificant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r val-ues:0.362, -0.428, 0.672, 0.575, all P<0.01) . Conclusion Serum GP73 level increases with progres-sion of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis.
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n positive blood culture, and they are resistant to a variety of antimicrobial agents, which should be called attention.
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Objective:To investigate frequency of blood stasis syndrome(BSS) defined by traditional Chinese medicine in cerebral infarction and its correlations with carotid atherosclerotic plaque(CAP).Methods: All subjects comprised 151 patients aged 40 to 80 years(Mean ? SD age,65 ?11 years) with 67.9% for males and 32.1% for females.With the use of ACUSON7 color Doppler ultrasound,carotid atherosclerosis was evaluated by the plaque score,the left plaque score,the right plaque score,the numbers of the plaque respectively as defined by the sum of all plaque heights in bilateral carotid arteries.On the basis of neurological signs and symptoms,medical history,and brain MRI,we diagnosed stroke and its subtypes as follows: stroke(n=117),and vertebrobasilar insufficiency(VBI)(n=34) without the history of the stroke,which were based on Diagnostic Criteria for Cerebral Vascular Diseases in 2005.Diagnosis for syndromes defined by traditional Chinese medicine were made according to Diagnostic Criteria for Stroke in 1994.One-way ANOVA was used in comparison between groups,and multivariant Logistic Regression Analysis was conferred in correlations between several variables.Results: 47.0% of all cases with cerebral infarction presented the BSS,with as lower than syndrome of fire-heat(51.0%),as but significantly higher than syndrome of Qi deficiency(32.0%),liver-wind syndrome(27.0%),phlegm syndrome(23.0%) and syndrome of asthenic yin causing predominant yang(6.0%).There is a significant difference between groups for 44(79.0%) cases of 56 patients with cerebral infarction and the BSS have CAP,and only 35(57.0%) cases of 61 patients with cerebral infarction but without the BSS have CAP(P
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0.05). There was no correlation between Bcl-2 and Fas positive cells and acetylcholine receptor antibody serum titre, disease grouping, age and sex in patients with or without hyperplastic thymic and thymoma.Conclusions In MG patients, the expression of Bcl-2 in hyperplastic thymus is upregulated. There is no correlation between the expression of apoptotic genes Bcl-2 and Fas and clinic relative factors.